4S
Scandinavian simvastatin survival study;
6C trial
cooperative colorectal cancer combination chemotherapy clinical;
AAASPS
African-American antiplatelet stroke prevention study;
AASK
African-American study of kidney disease and hypertension
ABC study
Association of Black Cardiologists study of hypertension;
ABCD
alternans before cardioverter-defibrillatorappropriate blood pressure control in diabetes
AbESTT
abciximab [ReoPro™] in emergent stroke treatment trial
ACADEMIC
azithromycin in coronary artery disease: elimination of myocardial infection with chlamydia
ACAS
asymptomatic carotid atherosclerosis study;
ACCENT
A Crohn's disease clinical trial evaluating infliximab in a new long-term treatment regimen
ACCESS
acute candesartan cilexetil evaluation in stroke survivorsa case control etiological study of sarcoidosis
ACCORD
action to control cardiovascular risk in diabetes
ACES
Avelox™ clinical experience studyazithromycin and coronary events study
ACME
angioplasty compared to medicine
ACIP
asymptomatic cardiac ischemia pilot study
ACRE
appropriateness of coronary revascularization
ACST
asymptomatic carotid surgery trial
ACT
angioplasty compliance trialattacking claudication with ticlopidine
ACTION
a clinical trial in overt nephropathy; actinomycin eluting stent improves outcomes by reducing neointimal hyperplasiaa coronary disease trial investigating outcome with nifedipine GITS
ACUTE
analysis of coronary ultrasound thrombolysis endpoints in acute myocardial infarction; Angiosonicsassessment of cardioversion utilizing transesophageal echocardiography;
ADAM
Amsterdam duration of antiretroviral medication studyaneurysm detection and management study
ADAPT
Alzheimer's disease anti-inflammatory prevention trial;
ADCS
Alzheimer's disease cooperative study
ADEMEX
adequacy of peritoneal dialysis in Mexico; sponsor: Baxter Healthcare Corporation
ADEPT
advanced elements of pacing trial; sponsor: Medtronic
ADMIRAL
abciximab before direct angioplasty and stenting in myocardial infarction regarding acute and long-term followup
ADMIT
arterial disease multiple intervention trial
ADONIS
aspirin dose optimized in noncardioembolic ischemic stroke
ADOPT
a diabetes outcome progression trial;
ADOPT-A
atrial dynamic overdrive pacing trial-A
ADVANCE
a dosing evaluation of a vasopressin antagonist in CHF patients undergoing exercise
AEGIS
alternative graft investigational study;
AFCAPS
Air Force coronary atherosclerosis prevention study
AFFIRM
atrial fibrilation followup: investigation of rhythm management
AFIB
atrial fibrillation investigation with bidisomide
AGENT
angiogenic gene therapy
AGIS
advanced glaucoma intervention study
A-HeFT
African-American heart failure trial;
AIR
aerosolized iloprost randomized placebo-controlled study; sponsor: Schering AG
AIST-ASH
acute ischemic stroke trial: oral aspirin vs intravenous heparin on stroke progression
ALERT
adjunctive Lamictal® in epilepsy and response to treatmentassessment of Lescol® in renal transplantation
ALIVE
adenosine lidocaine infarct zone viability enhancementamiodarone versus lidocaine in prehospital ventricular fibrillation evaluation; sponsor: Wyeth Pharmaceuticalsazimilide postinfarct survival evaluation;
ALLHAT
antihypertensive and lipid-lowering treatment to prevent heart attack trial;
ALLIANCE
aggressive lipid lowering to alleviate new cardiovascular endpoints
ALTS
ASCUS/LSIL triage study [ASCUS - atypical squamous cells of undetermined significance; LSIL - low-grade squamous intraepithelial lesion]
AMAZE
a multicenter trial using Atacand®-Zestril®* versus Zestril to evaluate the effects on lowering blood pressure [*Atacand as add-on therapy with Zestril]
AMIGO
AC2993: diabetes management for improving glucose outcomes; sponsor: Amylin Pharmaceuticals, Inc.
AMISTAD
acute myocardial infarction study of adenosine;
APASS
antiphospholipid antibody stroke study
APC
adenoma prevention with celecoxib;
APOCARD
Apomate™ imaging in cardiac transplant patients
APRES
angiotensin-converting enzyme inhibition post revascularization study
ARCH
amiodarone reduction in coronary heart
ARCHeR
Acculink™ for revascularization of carotids in high-risk patients
AREDS
age-related eye disease study
ARIC
atherosclerosis risk in communities
ARMS
APSAC reocclusion multicenter study
ARREST
AngioRad™ radiation for restenosis;
ARTISTIC
AngioRad™ radiation therapy for in-stent restenosis intracoronary;
ASAP
azimilide supraventricular arrhythmia program;
ASCENT
ACS stent clinical equivalence in de novo lesions trial
ASCOT
Anglo-Scandinavian cardiac outcome trial
ASPECT
anticoagulants in the secondary prevention of events in coronary thrombosis;
ASPEN
atorvastatin [Lipitor™] study for the prevention of endpoints for patients with NIDDM
ASSENT
assessment of the safety and efficacy of a new thrombolytic [TNKase™];
ASTIS
autologous stem cell transplantation international scleroderma trial
ASTRID
atrial sensing trial to prevent inappropriate detections
ASTRONAUT
acid suppression trial: ranitidine [Zantac®] versus omeprazole [Prilosec®] for NSAID-associated ulcer treatment
ATAC
Arimidex (anastrozole), tamoxifen and combination therapyArimidex (anastrozole) and tamoxifen alone or in combination
ATBAT
anticoagulant therapy with bivalirudin [Angiomax™] to assist in PCI 1st inning trial (PCI in HIT/HITTS)
ATICH
antifibrinolytic therapy in acute intracerebral hemorrhage
ATLAS
Acolysis during treatment of lesions affecting saphenous vein bypass grafts; Angiosonics' Acolysis System™assessment of treatment with lisinopril and survival;
ATLANTIC
angina treatments – lasers and normal therapies in comparison
ATLANTIS
alteplase thrombolysis for acute noninterventional therapy in ischemic stroke
AT LAST
antiretroviral trial looking at sex and treatment
AtoZ
Aggrastat® to Zocor® study; sponsor: Merck
ATRIA
anticoagulation and risk factors in atrial fibrillation
ATS
amblyopia treatment study
ATTRACT
anti-TNF trial in rheumatoid arthritis with cA2 treatment; anti-TNF trial in rheumatoid arthritis with concomitant therapy
AVASIS
aspirin versus anticoagulants in symptomatic intracranial stenosis
AVERT
artificial valve endocarditis reduction trialatorvastatin versus revascularization treatments
AVID
antiarrhythmics versus implantable defibrillators
AWESOME
angina with extremely serious operative mortality evaluation
AZACS
azithromycin in acute coronary syndromes
BARIBARI 2D
bypass angioplasty revascularization investigationbypass angioplasty revascularization investigation 2 diabetes;
BARS
Beaumont alcohol restenosis study
BASC
blood pressure in acute stroke collaboration
BATMAN
BiodivYsio® batimastat SV stent versus balloon angioplasty for the reduction of restenosis in small coronary arteries;
BCPT
breast cancer prevention trial
BEAT
bucindolol evaluation in acute myocardial infarction trial;
BECAIT
bezafibrate coronary atherosclerosis intervention trial
BELLES
beyond endorsed lipid lowering with EBCT scannings
BENEFIT
Betaferon® [Betaseron® in U.S.] in newly emerging MS for initial treatment; information
BENESTENT
Belgium Netherlands stent
BERT
beta energy restenosis trial;
BESMART
beStent™ in small arteries
BEST
beta-blocker evaluation of survival trial;
BEST-ICD
beta-blocker evaluation of survival trial plus ICD
BETTER
beta radiation trial to eliminate restenosis;
BHACAS
beating heart against cardioplegic arrest studies
BIP
bezafibrate infarction prevention
BLIND-DATE
blinded withdrawal of deprenyl in the DATATOP extension trial
BLOSS
beta blocker length of stay study
BPAV
balloon prophylaxis of aneurysmal vasospasm
BRAINS
Bayer randomized acute ischemia neuroprotectant studybiochemical research and information study
BRAVO
beta radiation for treatment of arteriovenous graft outflow; sponsor: Novoste Corporation [Corona™ system] blockade of the GP IIb/IIIa receptor to avoid vascular occlusion;
BREATHE-1
bosentan [Tracleer™]: randomized trial of endothelin receptor antagonist therapy for pulmonary hypertension
BRILLIANT
batimastat (BB-94) antirestenosis trial utilizing the BiodivYsio® local drug delivery PC stent;
BRITEBRITE-SVG
beta radiation to reduce in-stent restenosis; beta radiation to reduce in-stent restenosis for saphenous vein bypass grafts
CABERNET
carotid artery revascularization using the Boston Scientific EPI FilterWire EX and the EndoTex NexStent
CACHET
comparison of abciximab complications with Hirulog® [Angiomax™ as of 1999] ischemic events trial
CADILLAC
controlled abciximab [ReoPro™] and device investigation to lower late angioplasty complications
CAESAR
Canada, Australia, Europe, South Africa AIDS study;
CALM
candesartan and lisinopril microalbuminuria study
CALM-PD
comparison of the agonist pramipexole vs. levodopa on motor complications in Parkinson disease
CALYPSO
cylexin as an adjunct to lytic therapy to prevent superoxide reflow injury
CAMELOT
comparison of amlodipine versus enalapril [Lipitor®] to limit occurrences of thrombosis
CAMEO
cerebral aneurysm multicenter European Onyx™
CANDLE
candesartan versus losartan efficacy comparison;
CAPARES
coronary angioplasty amlodipine restenosis study
CAPRICORN
carvedilol post infarction survival control in left ventricular dysfunction
CAPRIE
clopidogrel versus aspirin in patients at risk of ischemic events;
CAPT
complications of AMD [age-related macular degeneration] prevention trial
CAPTEN
captopril after thrombolysis trial;
CAPTIM
comparison of angioplasty and prehospital thrombolysis in acute myocardial infarction
CAPTIN
captopril before reperfusion in acute myocardial infarctioncaptopril plus tissue plasminogen activator following acute myocardial infarction
CAPTURE
c7E3 antiplatelet therapy in unstable refractory angina
CARDIA
coronary artery risk development in young adults
CARDS
collaborative atorvastatin [Lipitor™] and diabetes study
CARE
calcium antagonist in reperfusion; cholesterol and recurrent events; carvedilol atherectomy restenosis;
CARE-HD
coenzyme Q10 and remacemide: evaluation in Huntington disease
CARE-HF
cardiac resynchronization - heart failure; European complement to U.S./Canada MIRACLE study
CARISA
combination assessment of ranolazine in stable angina;
CARMEN
carvedilol ACE inhibitors remodelling mild heart failure evaluation
CART
Canadian antioxidant restenosis trial
CASES
Canadian activase for stroke effectiveness study
CASH
cardiac arrest study-Hamburg
CAST
cardiac arrhythmia suppression trial;
CASTLE
candesartan amlodipine study of tolerability and efficacy
CAT
Chinese ACE inhibitor in acute myocardial infarction trialcardiomyopathy trial
CATAPULT
cisplatin and tirapazamine in subjects with advanced previously untreated non–small cell lung tumors
CATIE
clinical antipsychotic trials of intervention effectiveness
CATS
Canadian American ticlopidine studycaptopril and thrombolysis study
CAVATAS
carotid and vertebral artery transluminal angioplasty study
CBT-CD
cognitive behavior therapy for the chronic depressions;
CEDARS
comprehensive evaluation of defibrillators and resuscitative shock
CEOS
congenital esotropia observational study
CHAMP
children's HIV and AIDS model programcombination chemotherapy and mortality prevention
CHAMPIONS
controlled high-risk subjects Avonex™ MS prevention in ongoing neurologic surveillance
CHAMPS
controlled high-risk subjects Avonex™ MS prevention study
CHARM
candesartan cilexitil [Atacand™] in heart failure assessment of reduction mortality and morbidity
CHEESE
comparative trial of HIV-infected patients evaluating efficacy and safety of saquinavir-enhanced oral formulation and indinavir given as part of a triple drug therapy;
CHF-STAT
congestive heart failure survival trial of antiarrhythmic therapy
CHRISTMAS
carvedilol hibernation reversible ischemia trial; marker of success
CHS
cardiovascular health studyCharleston heart studycommunity health studyCongenital Heart Surgeons Society studycoronary heart study
CIBIS
cardiac insufficiency bisoprolol study
CIDS
Canadian implantable defibrillator study; sponsor: Medtronic
CIGTS
collaborative initial glaucoma treatment study
CLASS
celecoxib [Celebrex®] long-term arthritis safety studyclomethiazole acute stroke study
CLASSICS
clopidogrel [Plavix™] aspirin stent international cooperative study
CLASS-IHT
clomethiazole acute stroke study in ischemic, hemorrhagic, and tPA treated stroke
CLEERE
collaborative longitudinal evaluation of ethnicity and refractive error
COAST
heparin-coated stents in small coronary arteries
COCAD
cognitive outcomes in coronary artery disease
COLA
carvedilol open label assessment
COMBINE
combining medications and behavorial interventions;
COMET
carvedilol or metoprolol European trial
COMMA
compliment inhibition in myocardial infarction treated with percutaneous transluminal coronary angioplasty [evaluation of IV dosing regimens of h5G1.1-scFv]; sponsors: Procter & Gamble and Alexion Pharmaceuticals
COMPANION
comparison of medical therapy, pacing and defibrillation in chronic heart failure; Guidant Corporation
COMPLY
compliment inhibition in myocardial infarction treated with thrombolytics [evaluation of IV dosing regimens of h5G1.1-scFv]; sponsors: Procter & Gamble Pharmaceuticals and Alexion Pharmaceuticals
COMS
collaborative ocular melanoma study
CONVINCE
controlled onset verapamil investigation of cardiovascular endpoints
COOL
cardiovascular thrombolytic to open occluded lines [t-PA]
COOL AID
cooling for acute ischemic brain damage;
COOL MI
cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction;
COPERNICUS
carvedilol [Coreg®] prospective randomized cumulative survival
COPPA
clinical outcomes from the prevention of postoperative arrhythmia
CORE
continuing outcomes relevant to Evista™
COSS
carotid occlusion surgery study
COURAGE
clinical outcomes utilizing revascularization and aggressive drug evaluation;
COURT
a randomized trial of contrast media utilization in high risk PTCA
CRASH
corticosteroid randomization after significant head injury
CREDO
clopidogrel [Plavix™] for reduction of events during observation
CREST
carotid revascularization endarterectomy vs stenting trial
CRUISE
can routine ultrasound influence stent expansion
CURE
clopidogrel in unstable angina to prevent recurrent ischemic events
DAIS
diabetes atherosclerosis intervention study
DAISY
diabetes autoimmunity study in the young
DATATOP
deprenyl and tocopherol antioxidative therapy of parkinsonism
DAVID
dual-chamber and VVI implantable defibrillator; see
DEBATE
Doppler endpoints balloon angioplasty trial Europe;
DECOPI
la desobstruction coronaire en post-infarctus
DEFINITE
defibrillators in nonischemic cardiomyopathy treatment evaluation
DEFUSE
diffusion-weighted imaging evaluation for understanding stroke evaluation;
DESTINI-CFR
Doppler endpoints stenting international investigation - coronary flow reserve;
DIADS
depression in Alzheimer disease study
DIAGNOSIS
diffusion-weighted imaging assessment of the genuine need for other studies in ischemic stroke
DIAMOND
distensibility improvement with ALT-711 remodeling in diastolic heart failure
DIAMOND CHF
Danish investigators of arrhythmia and mortality on dofetilde congestive heart failure;
DIGAMI
diabetes mellitus insulin-glucose infusion in acute myocardial infarction
DMIST
digital mammographic imaging screening trial
DINAMIT
defibrillation in acute myocardial infarction trial
DIRECT
diabetic retinopathy candesartan trial; candesartan cilexetil (Atacand®)
DIRECTOR
direct stenting study with Orbus R stent™; sponsor: Orbus Medical Technologies
DISC
disability in strategies for care
DISTINCT
BiodivYsio™ stent in controlled trial
DPT-1
diabetes prevention trial - type 1;
DREAM
diabetes reduction approaches with ramipril and rosiglitazone medications
DYSBOT
Dysport and Botox study;
EAGAR
estrogen and graft atherosclerosis research trial
EARS
European atherosclerosis research study
ECCO 2000
effects of citicoline (CerAxon™) on clinical outcome - 2000 mg;
EDGE™
evaluation of daptomycin [Cidecin™] in gram-positive entities
EDGECAP
evaluation of daptomycin [Cidecin™] in gram-positive entities in the treatment of community-acquired pneumonia
EDGESST
evaluation of daptomycin [Cidecin™] in gram-positive entities in the treatment of complicated skin and soft tissue infections
EDGEUTI
evaluation of daptomycin [Cidecin™] in gram-positive entities in the treatment of complicated urinary tract infection
ED-IMPACT
emergency department impedance cardiography-aided assessment changes therapy; sponsor: CardioDynamics International
EFICAT
ejection fraction in cardiac transplant patients
EGASIS
early GABA-ergic activation sin troke
ELECT
evaluating enoxaparin [Lovenox®] clotting times; see
ELITE
evaluation of losartan in the elderly
ELLDOPA
earlier versus later levodopa in Parkinson disease
ENABLE
endothelin antagonist bosentan for lowering cardiac events in heart failure
ENCORE
evaluation of nifedipine and cerivastatin on the recovery of endothelial function
ENRICHD
enhancing recovery in coronary heart disease
ENTIRE
enoxaparin and TNK-tPA with or without GP IIb/IIIa inhibitor as reperfusion strategy in ST elevation MI [TIMI-23];
EPHESUS
eplerenone neurohormonal efficacy and survival study; eplerenone post-AMI heart failure efficacy and survival study
EPIC
evaluation of c7E3 for prevention of ischemic complications
EPILOG
evaluation in PTCA to improve long-term outcome with abciximab GP IIb/IIIa blockade;
EPISTENT
evaluation of platelet IIb/IIIa inhibitor for stenting trial
ERA
early rheumatoid arthritis (RA) studyenoxaparin restenosis after angioplasty studyestrogen replacement and atherosclerosis study
ERASE
emergency room assessment of sestamibi for evaluation of chest pain
ERGO
etomoxir for the recovery of glucose oxidation
ER-TIMI
early Retavase™ - thrombolysis in myocardial infarction
ESCAPE
evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness
ESPRIT
enhanced suppression of the platelet IIb/IIIa receptor with Integrilin™ therapyEuropean study of the prevention of reocclusion after initial thrombolysisevaluation of subcutaneous proleukin in a randomized international trial
ESPS2
European stroke prevention study 2
ESSENCE
efficacy and safety of subcutaneous enoxaparin in non–Q-wave coronary events;
ESSENTIAL
the studies of oral enoximone therapy in advanced heart failure; sponsor: Myogen, Inc.
ETHECC
evaluation of Thymitaq™ in hepatocellular carcinoma
ETROP
early treatment of retinopathy of prematurity
Euro-SPAH
European-sonotherapy prevention of arterial hyperplasia
EVIDENCE
evidence for interferon dose-effect: European-North American comparative efficacy study [Rebif® v. Avonex™ in relapsing-remitting multiple sclerosis (RRMS)]
EVIDENT
endovascular investigation determining the safety of a new tacrolimus-eluting stent graft; sponsor: JOMED N.V.
EXCITE
evaluation of oral xemilofiban in controlling thrombotic events;
EXCITe
extremity constraint-induced therapy
EXCLAIM
extended clinical prophylaxis in acutely ill medical patients [Lovenox™ (enoxaparin) postmarketing (phase IV) trial]; sponsor: Aventis
FACET
fosinopril versus amlodipine cardiovascular events randomized trial
FAME
fluvastatin [Lescol®] assessment of morbi-mortality in the elderly
FASTER
fibrinolytic and Aggrastat® ST elevation resolution; first abarelix depot study for treating endometriosis rapidlyfirst and second trimester evaluation of risk
FAST-MAG
field administration of stroke therapy - magnesium
FIELD
fenofibrate [TriCor®] intervention and event lowering in diabetes
FIRST
Flolan (dobutamine) international randomized survival trialfirst trimester integrated risk screening for trisomy
FLARE
fluvastatin [Lescol®] angiographic restenosis
FOOD
feed or ordinary diet
FOSIT
Fosamax® international trial
FRAXIS / FRAX.I.S.
Fraxiparine® in ischemic syndromes
FRIC
Fragmin® in unstable coronary artery disease
FRISC
fast revascularization during instability in coronary artery disease Fragmin® during instability in coronary artery disease
FROSTY
Freezor™ trial of supraventricular tachycardia
FUSION
fractional flow reserve and ultrasound indices for objective narrowing assessment
GART study
genotypic antiretroviral resistance testing
GEMS
Ginkgo biloba evaluation memory study
GISEN
gruppo Italiano di studi epidemiologici in nefrologia
GUSTO
global utilization of streptokinase and tPA for occluded arteries;
GUSTO-SPEED
global utilization of streptokinase and tPA for occluded arteries–strategies for patency enhancement in the emergency department
HALT-C
hepatitis C antiviral long-term treatment to prevent cirrhosis;
HANDLS
health aging in nationally diverse longitudinal samples
HARDBALL
heart allograft rejection: detection with breath alkanes in low levels
HeADDFIRST
hemicraniectomy and durotomy for deterioration from infarction relating swelling trial
HEART
healing and early afterload reducing therapy
HEAT 2
hypertension endothelin antagonist treatment
HEME
hemorrhage early MRI evaluation
HERO
Hirulog® early reperfusion/occlusion trial
HERS
heart and estrogen/progestin replacement studyHIV epidemiology research study
HESTIA
home evaluation of stroke induced aid
HIPS
heparin infusion prior to stenting;
HIT
HDL-cholesterol intervention trialhirudin for the improvement of thrombolysis
HOPE
heart outcomes prevention evaluation;
HOPE-TOO
heart outcomes prevention evaluation - the ongoing outcomes
HORIZON
health outcomes and reduced incidence with zoledronic once yearly
HOT
hypertension optimum treatment
HPS
heart protection study
HRS
health and retirement study
HYVET
hypertension in the very elderly trial
ICE-IT
intravascular cooling adjunctive to primary coronary intervention
ICSS
international carotid stenting study (CAVATAS-2)
IDEAL
incremental decrease in endpoints through aggressive lipid lowering Iressa® dose evaluation in advanced lung cancer
IDNT
irbesartan [Avapro®] in diabetic nephropathy trial
IHAST
intraoperative hypothermia for aneurysm surgery trial
IMAGES
intravenous magnesium efficacy in stroke
IMAGINE
ischemic management with Accupril™ post bypass graft via inhibition of converting enzyme
IMPACT
Integrilin™ to manage platelet aggregation to prevent coronary thrombosisinternational mexiletine or placebo antiarrhythmic coronary trial;international multiple sclerosis secondary progressive Avonex™ controlled trial
IMPRESS
inhibition of metalloprotease by BMS-186716 in a randomized exercise and symptoms study;
IMS
interventional management of stroke study
INCOMIN
independent comparison of interferon [Betaseron® v. Avonex™ in relapsing-remitting multiple sclerosis (RRMS)]
InDDEx
investigation into delay to diagnosis of Alzheimer disease with Exelon™
INHIBIT
intimal hyperplasia inhibition with beta in-stent trial
INSIGHT
international nifedipine once-daily study – intervention as a goal in hypertension treatment
INTACT
Iressa® non–small cell lung cancer trial assessing combination treatment
INTEGRITI
Integrilin® and tenecteplase [TNKase™] in acute myocardial infarction;
InTIME
intravenous nPA for treatment of infarcting myocardium early;
INTrEPID
investigation of non–transplant-eligible patients who are inotrope dependent; see
INTRO-AMI
Integrilin® and reduced dose of thrombolytic in acute myocardial infarction
IONA
impact of nicorandil in angina
IONDT
ischemic optic neuropathy decompression trial
IRAS
insulin resistance atherosclerosis study
IRMA 2
irbesartan [Avapro®] microalbuminuria type 2
IRIS
Isostent for restenosis intervention study
ISAAC
international study of asthma and allergies in childhood
ISAR
intracoronary stenting and antithrombotic regimen
ISAR-STEREO
intracoronary stenting and angiographic results - strut thickness effect on restenosis outcome
ISAT
international subarachnoid aneurysm trial
ISTICH
international surgical trial in intracerebral hemorrhage
ITT
intraventricular thrombolysis trial
IVAT
intermediate sized vessel atherectomy trial
L-CAD
lipid-coronary artery disease [pravastatin
LACI
laser angioplasty for critical ischemia;
LAMP
locally advanced multimodality protocol;
LARS
laser angioplasty in restenosed stents
LaSRS
late steroid rescue study
LATE
late assessment of thrombolytic efficacy;
LEADER
lower extremity arterial disease event reduction
LIDO
levosimendan [Simdax™] infusion versus dobutamine in low output heart failure
LIDS
lumbar invertebrae disk study [device trial]
LIFE
losartan intervention for endpoint reduction in hypertension
LIMB
ultrasound lysing in lower extremities to minimize blood clots; Angiosonics
LIMIT
long lesion intracoronary radiation to minimize intimal hyperplasia trial
LIPID
long-term intervention with pravastatin in ischemic disease;
LONG WRIST
Washington radiation for in-stent restenosis trial for long lesions
Look AHEAD
action for health in diabetes [Xenical; long-term study of effects of weight loss in type 2 diabetics]
L-TAP
lipid treatment assessment project
LV3P-CHF
left ventricular pacing in pacemaker patients with congestive heart failure (CHF)
MADIT
multicenter automatic defibrillator implantation trial
MAGIC
magnesium in coronay arteries
MARISA
monotherapy assessment of ranolazine in stable angina;
MARRVEL
magnetic resonance radionuclide ventriculography and echocardiography in left ventricular function
MARVAL
microalbuminuria reduction with valsartan [Diovan®]
MASH
magnesium and acetylsalicylic acid in subarachnoid hemorrhage
MATCH
management of atherothrombosis with clopidogrel [Plavix™] in high-risk patients with recent transient ischemic attack or ischemic stroke
MDC
metoprolol in dilated cardiomyopathy
MDPIT
multicenter diltiazem post infarction trial
MEDENOX
prophylaxis in medical patients with enoxaparin [Lovenox®]
MERIT-HF
metoprolol CR/XL (controlled release) randomized intervention trial in heart failure;
MIAMI
Multi-Link® Duet™ coronary stent in acute myocardial infarction
MICRO-HOPE
microalbuminuria, cardiovascular, and renal outcomes (HOPE [heart outcomes prevention evaluation] substudy)
MIRA
minocycline in rheumatoid arthritis
MIRACL
myocardial ischemia reduction with aggressive cholesterol lowering
MIRACLE
multicenter InSync™ randomized clinical evaluation (North America)
MIRACLE ICD
multicenter InSync™ randomized clinical evaluation implantable cardioverter defibrillator
MIRAGE
multi-institutional research in Alzheimer genetic epidemiology
MMAIT
malignant melanoma active immunotherapy trials; [Canvaxin™]
MMSS
MyoVive™ marketing surveillance study;
MOBILE
more patency with beta for in-stent restenosis in the lower extremity
MOCHA
multicenter oral carvedilol [Coreg®] heart failure assessment
MONICA
monitoring trends and determinants in cardiovascular disease
MORE
multiple outcomes of raloxifene evaluation
MOST
mode selection trial in sinus node dysfunction
MOXCON
moxonidine congestive heart failure trial;
MRFIT
multiple risk factor intervention trial
MR IMAGES
magnetic resonance in intravenous magnesium efficacy in stroke
MSMI
multicenter study of myocardial ischemia
MUST
medication use studies; multicenter stent study; multicenter stents ticlopidine;
MUST EECP
multicenter study of enhanced external counterpulsation [EECP®]
MUSTIC
multisite stimulation in cardiomyopathy
MUSTT
multicenter unstable tachycardia trial; multicenter unsustained tachycardia trial;
NAFT
North American Fragmin® trial
NASCET
North American symptomatic carotid endarterectomy trial;
NAVIGATOR
nateglinide and valsartan in impaired glucose tolerance outcomes research;
NETT
national emphysema treatment trial
NETWORK
Network of general practitioners and hospital physicians involved in the study of low versus high doses of enalapril in patients with heart failure trial
NICE
Novacor® inflow conduit evaluation
NICE 3
national investigators collaborating on enoxaparin [Lovenox®]
NOCIS
new onset Crohn's intervention study
OASIS / OASIS-2
organization to assess strategies for ischemic syndromes
OAT
open artery trial
OBJECT
overactive bladder: judging effective control and treatment [Ditropan XL v. Detrol]
OCBAS
optimal coronary balloon angioplasty versus stent
OCTAVE
omapatrilat [Vanlev™] cardiovascular treatment assessment versus enalapril
OHTS
ocular hypertension treatment study
OMNIUM
omeprazole [Prilosec®] versus misoprostol [Cytotec®] for NSAID-induced ulcer management
ONTARGET
ongoing telmisartan [Micardis®] alone and in combination with ramipril [Altace®] global endpoint trial
OPERA
omapatrilat [Vanlev™] in persons with enhanced risk of atherosclerotic events;
OPTIC
optimal pharmacological therapy in implantable cardioverter defibrillator patients
OPTIMAAL
optimal trial in myocardial infarction with the angiotensin II antagonist losartan
OPTIME-CHF
outcomes of a prospective trial of intravenous milrinone for exacerbations of chronic heart failure OPUS
orbofiban in patients with unstable coronary syndromes
ORBIT
oral glycoprotein IIb/IIIa receptor blockade to inhibit thrombosis;
OVERTURE
omapatrilat versus enalapril randomized trial of utility in reducing events;
PAC-A-TACH
pacing in atrial fibrillation and tachycardia
PACIFIC
potential angina class improvement for intramyocardial channels
PACT
Philadelphia Association of Clinical Trials studyplasminogen activator angioplasty compatibility trialprehospital application of coronary thrombolysisprourokinase in acute coronary thrombosis
PAMI
primary angioplasty in acute myocardial infarction;
PARADIGM
pramlintide for amylin replacement adjunct for diabetes in glycemic management;
PARAGON
platelet IIb/IIIa antagonism for the reduction of acute coronary syndrome events in the global organization network
PARIS
peripheral artery radiation investigational study [study of the Nucletron® Paris® leg artery radiation catheter]
PASS II
piracetam acute stroke study II search help: piracetam
PATH-CHF
pacing therapies for congestive heart failure
PAVE
post AV node ablation evaluation
PCDD
prevention of cardiovascular disease in diabetes
PCI-CURE
clopidogrel [Plavix®] in unstable angina to prevent recurrent ischemic events in patients undergoing percutaneous coronary intervention; companion to CURE study
PCPT
prostate cancer prevention trial
PDQUALIF
Parkinson('s) disease quality of life
PEACE
prevention of events with angiotensin converting enzyme [ACE] inhibitor therapy
PEECH™
prospective evaluation of EECP® in congestive heart failure; sponsor, Vasomedical, Inc.
PENTALYSE
synthetic pentasaccharide as an adjunct to fibrinolysis in ST-elevation acute myocardial infarction
PENTUA
pentasaccharide in unstable angina
PEPI
postmenopausal estrogen/progestin interventions study
PETHEMA
programa para el estudio y tratamiento de las hemopatÃas malignas[program for the study and treatment of malignant hemopathies]
PHADE
pneumatic HeartMate® assist as destination evaluation;
PHAROS
pilot Huntington at risk observational study
PIE
protease inhibitor experienced [study of Fortovase™ with Kaletra™]
PIVOT
prostate cancer intervention versus observation trial
PLESS
Proscar® long-term efficacy and safety study;
PLUS
propentofylline long-term use study
POEM
patency, outcomes and economics of MIDCAB;
POLAR
pilot study of low-temperature angiogenic revascularization
POST
posterior stroke trialpotassium-channel opening stroke trial
POWER
PTH for osteoporotic women on estrogen replacement [ALX1-11, a recombinant parathyroid hormone (PTH) formulation];
PRAGUE
primary angioplasty in patients transferred from general community hospitals to specialized PTCA units with or without emergency thrombolysis
PRAISE
prospective randomized amlodipine survival evaluation
PRECEDENT
prospective randomized ectopy evaluation on dobutamine or Natrecor® (nesiritide) therapy; Scios Inc.
PREDICT-HD
neurobiologic predictors of Huntington disease onset
PREFER
preference study of Gengraf™ compared to Neoral™ in stable solid organ transplant subjects
PREPARE
prevent postmenopausal Alzheimer’s with replacement estrogens (a.k.a. Alzheimer('s) disease prevention trial)
PRESENT
preliminary safety evaluation of nanoporous tacrolimus-eluting stents;
PRESTO
Parkinson('s) rasagiline: efficacy & safety in the treatment of "OFF"prevention of restenosis with tranilast and its outcomes
PREVENT
prevention of recurrent venous thromboembolismprogram in ex vivo vein graft engineering via transfectionproliferation reduction with vascular energy trial; sponsor: Guidant Corp.prospective randomized evaluation of the vascular effects of Norvasc® trial
PRIDE
protection during saphenous vein graft intervention to prevent distal embolization);
PRIME
pramipexole in minority persons with Parkinson('s) disease: efficacyprogram for irbesartan mortality and morbidity evaluations [consists of two studies: IRMA 2 and IDNT]
PRIMO-CABG
pexelizumab for reduction in infarction and mortality in coronary artery bypass graft surgery
PRINCE
pravastatin inflammation/CRP evaluation
PRINCESS
prevention of reinfarction with early treatment by cerivastatin study
PRISM-PLUS
platelet receptor inhibition for ischemic syndrome management in patients limited to very unstable signs and symptoms;
PROACT
prolyse in acute cerebral thromboembolism
PROACTION
prospective randomized outcomes study of acutely decompensated congestive heart failure treated initially in outpatients with Natrecor®;
PROBE
Primacor (milrinone lactate) for optimization of beta-blocker efficacy
PROBE evaluation
prospective, randomized, open, blinded endpoint;
PROBIT
promotion of breastfeeding intervention trial
PROGENI
Parkinson('s) research: the organized genetics initiative
PROGRESS
perindopril [Aceon®] protection against recurrent stroke study
PROMPT
profiling Remicade onset with methotrexate in a prospective trial
PROSPER
prospective study of pravastatin in the elderly at risk
PROTEKT
prospective resistant organism tracking for the ketolide telithromycin [Ketek™]
PROVE IT
pravastatin or atorvastatin evaluation and infection therapy;
PROWESS
recombinant human activated protein C [Xigris™] worldwide evaluation in severe sepsis
PSYCLOPS
psychosis and clozapine in Parkinson's disease
PTAMD
prophylactic treatment of AMD [age-related macular degeneration]
PURSUIT
platelet glycoprotein IIb/IIIa in unstable angina: receptor suppression using Integrilin™ therapy
QoLITY
quality of life trial hypertension;
QUIET
quinapril [Accupril™] ischemic event trial
RACECAR
restenosis and clinical evaluation in coronary arteries;
RALES
randomized Aldactone® (spironolactone) evaluation study for congestive heart failure;
RAPID
radiation after PTA is done; sponsor: Radiance Medical Systems [RDX™ coronary radiation delivery catheter] rapid-acting Parkinson('s) drug
RAPPORT
ReoPro® and primary PTCA organization and ramdomized trial
RAVEL
randomized study with the sirolimus-eluting Bx Velocity™ balloon-expandable stent [Cypher™]; REACH
rehabilitation among women with coronary heart diseaseresearch on endothelin antagonism in chronic heart failure;
REACT
rapid early action for coronary treatment; University of Minnesota and JAMA 2000;283:3223-3229 [July 5, 2000]
ReALIZe
research to assess the long-term impact of Zomaril™
RECIFE
reduction of cholesterol in ischemia and function of the endothelium
REDHOT
rapid emergency department heart failure outpatient trial[Trial to evaluate clinical utility of the Triage® BNP test in assessing effectiveness of therapy in the management of CHF.]
REGRESS
regression growth evaluation statin study
REIN
ramipril efficacy in nephropathy
REMATCH
randomized evaluation of mechanical assistance therapy as an alternative in congestive heart failure;
RENAAL
reduction in endpoints in patients with non–insulin-dependent diabetes mellitus with the angiotensin II antagonist losartan
RENAISSANCE
randomized Enbrel® North American strategy to study antagonism of cytokines
RESPECT
risk evaluation and stroke prevention in the elderly - cerivastatin trial;
RESTOR
R stent™ efficacy and safety trial Orbus; sponsor: Orbus Medical Technologies
RESTORE
randomized efficacy study of tirofiban for outcomes and restenosis;
REVERSAL
reversal of atherosclerosis with Lipitor™
REVERT
reversal of ventricular remodeling with Toprol-XL®;
RHYTHM
resynchronization for hemodynamic treatment for heart failure management
RID-HD
riluzole dosing in Huntington disease
RITZ-2
randomized intravenous tezosentan
ROSTER
rotational atherectomy versus balloon angioplasty for diffuse in-stent restenosis
RUTH
raloxifene use for the heart;
SADHAT
sertraline (Zoloft®) antidepressant heart attack trial
SADHART
sertraline antidepressant heart attack randomized trial
SAFE
safety after fifty evaluation
SAFER
saphenous vein graft angioplasty free of emboli randomized trial;
SAFE-T
sotalol and amiodarone atrial fibrillation effectiveness trial
SAGE
study assessing goals in the elderly
SAPPHIRE
systolic and pulse pressure hemodynamic improvement by restoring elasticity;
SARECCO
stent or angioplasty after recanalization of chronic coronary occlusions
S.A.V.S.
Synercid® as an alternative to vancomycin in staph[ylococcal infections] SAVS
SCD-HeFT or SCDHeFT
sudden cardiac death/heart failure trial
SCRIP
study of cardiovascular risk intervention by pharmacists
SCRIPPS
Scripps coronary radiation to inhibit proliferation post stenting
SEAL
simple and effective arterial closure study;
SEARCH
study of effectiveness of additional reductions of cholesterol and homocysteine
SECURE
study to evaluate carotid ultrasound changes in patients treated with ramipril [Altace®] and vitamin E
SELECT
selenium and vitamin E cancer prevention trial; description
SELENA
safety of estrogens in lupus erythematosus national assessment
SHARP
subcutaneous heparin and angioplasty restenosis prevention
SHELTER
stenting of high risk patients extracranial lesions trial with emboli removal;
SHEP
systolic hypertension in the elderly program
SHIPS
study of a home intervention post stroke
SHOCK
should we emergently revascularize occluded coronaries for cardiogenic shock
SHOW
study of health outcomes in weight loss
SICCO
stenting in chronic coronary occlusion
SIESTA
snooze-induced excitation of sympathetic triggered activity
SILCAAT
study of interleukin-2 (IL-2) in people with low CD4+ T-cell counts on active anti-HIV therapy; Chiron Corporation
SILENT
sonotherapy for in-lesion elimination of neointimal tissue; sponsor: PharmaSonics Inc.; also see
SILVER
systolic hypertension interaction with left ventricular remodeling; sponsor: Alteon Inc. [ALT-711]
SIRIUS
a multicenter randomized double-blind study of the sirolimus-coated Bx Velocity™ stent [referred to as Cypher™ sirolimus-eluting stent] in the treatment of patients with de novo coronary artery lesions; sponsor: Cordis search help: s/l "serious"
SIROCCO
sirolimus-coated Cordis S.M.A.R.T™ nitinol self-expanding stent in the treatment of obstructive superficial femoral artery disease
SMART
second manifestations of arterial diseaseserum markers acute myocardial infarction and rapid treatmentstrategies for the management of antiretroviral therapystudy of medicine versus angioplasty reperfusion trialstudy of Microstent's ability to limit restenosis trialstudy of monoclonal antibody radioimmunotherapy; Synercid® microbiological assessment of resistance trends;
SMILE
survival of myocardial infarction long-term evaluation
SNAP
study of nitroglycerin and chest pain
SPAF
stroke prevention in atrial fibrillation
SPEED
strategies for patency enhancement in the emergency department
SPORT
spine patient ooutcomes research trialstent implantation post rotational atherectomy trial
SPORTIF-V
stroke prevention using oral thrombin inhibition in atrial fibrillation - V [5th series of SPORTIF trials];
SOLVD
studies of left ventricular dysfunction
SONIA
stroke outcomes and neuroimaging of intracranial atherosclerosis
SONORA
safety of Neoral outcomes in rheumatoid arthritis
S.O.N.O.R.A.SM
study of new onset rheumatoid arthritis; sponsor: Knoll Pharmaceutical Company
SoS
stent or surgery
SPARCL
stroke prevention by aggressive reduction in cholesterol levels
SPICE
study of protease inhibitor combination in Europe;
SPLASH
sonotherapy prevention of late arterial in-stent hyperplasia; sponsor: PharmaSonics, Inc.; also see
SPS3
stroke prevention of small subcortical strokes
SSITT
Swiss-Spanish intermittent trial
SSYLVIA
stenting in symptomatic atherosclerotic lesions of vertebral and intracranial arteries
STAR
study of tamoxifen and raloxifene;
STARS
standard treatment with activase to reverse stroke
START
saruplase and taprostene acute reocclusion trialSt. Thomas' atherosclerosis regression trialstudy of thrombolytic therapy with additional response following taprostenestent versus angioplasty restenosis trialstent versus directional coronary atherectomy randomized trialstents and radiation therapy; selection of thymidine analog regimen therapy;
STAT
stroke treatment with ancrod trial
Stent PAMI
stent primary angioplasty for myocardial infarction
STEP-BD
systematic treatment enhancement program for bipolar disorder; study description
STICH
surgical treatment for intracerebral hemorrhage
STOP
sonotherapy for the treatment of peripheral vascular disease; sponsor: PharmaSonics, Inc.
STOP-DUB
surgical treatments outcomes project for dysfunctional uterine bleeding
STOP-Hypertension
Swedish trial in old patients with hypertension;
STRATAS
study to determine Rotablator® and transluminal angioplasty strategy
STRENGTHSTRENGTH II
statin response examined by genetic HAP™ markers; sponsor: Genaissance Pharmaceuticals
STRESS
stent restenosis study
STRETCH
symptom, tolerability, response to exercise trial of candesartan cilexetil [Atacand™] in heart failure
STRIDE
sitaxsentan to relieve impaired exercise in pulmonary hypertension
SUDEP
sudden unexpected death in epilepsy
SWEDIC
Sweden diastolic carvedilol
SWIFT
should we intervene following thrombolysis
SWING
sound waves inhibit neointimal growth; sponsor: PharmaSonics Inc.; also see
SWISS
siblings with ischemic stroke study
SWOG
Southwest Oncology Group [an adult cancer clinical trials organization]; SWOG protocols by indication
SYMPHONY
sibrafiban versus aspirin to yield maximum protection from ischemic heart events post-acute coronary syndromes;
SYNERGY
superior yield of the new strategy of enoxaparin, revascularization, and glycoprotein IIb/IIIa inhibitors
TACT
trial to assess chelation therapy [EDTA chelation therapy for coronary artery disease]; sponsor: National Institutes of Health (NIH)
TACTICS
thrombolysis and counterpulsation to improve cardiogenic shock survivaltreat angina with Aggrastat® and determine costs of therapy with invasive or conservative strategies [TIMI-18]
TAIST
tinzaparin in acute ischemic stroke trial
TARGET
do tirofiban [Aggrastat®] and ReoPro give similar efficacy outcomes trial
TCAS
temperature control during aneurysm surgery
TexCAPS
Texas coronary atherosclerosis prevention study
TeqCES
Tequin® clinical experience study
TheraP
TheraSource™ Pd-103 for prevention of restenosis; sponsor: Theragenics Corporation [TheraSource™ intravascular brachytherapy system]
TIGER-PA
tirofiban given in the emergency room before primary angioplasty
TIME
trial of invasive vs. medical therapy in elderly patients with chronic CAD
TIMI
thrombolysis in myocardial infarction; thrombin inhibition in myocardial infarction
TNT
treating to new targets
TOAT
the open artery trial
TONE
trial of nonpharmacologic interventions in the elderly
TOP
treatment of osteoporosis with PTH [ALX1-11, a recombinant parathyroid hormone (PTH) formulation]; sponsor: NPS Pharmaceuticals
TOPIC
tobramycin once-daily prescribing in cystic fibrosis
TRACE
trandolapril cardiac evaluation studytrial of genetic assessment in breast cancer
TRAFFIC
therapeutic angiogenesis with FGF-2 (fibroblast growth factor) for intermittent claudication; sponsor: Chiron Corporation
TRANSCEND
telmisartan [Micardis®] randomized assessment study in ace intolerant subjects with cardiovascular disease
TREAT
tranilast restenosis following angioplasty trial
TREND
trial on reversing endothelial dysfunction
TROPHY
trial for preventing hypertension;
TRUST
Tenax® for the prevention of restenosis and acute thrombotic complications. A useful stent trial [Tenax-XR, a silicon carbide-coated stent]; sponsor: Biotronik, Inc.
TTT4CNV
transpupillary thermotherapy for choroidal neovascularization
TURBO
the ultrasound removal of blood clots in vein grafts; Angiosonics
TUSS
tuberculosis ultraviolet shelter study
UK-HEART
United Kingdom heart failure evaluation and assessment of risk trial
UKPDS
United Kingdom perspective diabetes study
UNAIDS PETRA
United Nations programme on HIV/AIDS perinatal transmission trial
VA-HIT
Veterans Administration HDL intervention trial
Val-HeFT
valsartan heart failure trial;
VALIANT
valsartan in acute myocardial infarction trial; Vascular Architects femoropopliteal suboptimal angioplasty aSpire™ stent trial; sponsor: Vascular Architects
VALUE
valsartan antihypertensive long-term use evaluation;
VANILA
ventricular arrhythmia needing intravenous lidocaine/amiodarone
VANQWISH
Veterans Affairs non–Q-wave infarction strategies in hospital
VERT
vertebral efficacy with risedronate therapy; risedronate (Actonel®)
VICTORY
elective and acute stenting of coronary arteries on Express™ [coronary stent] system; sponsor: Boston Scientific
VIGOR
Vioxx® gastrointestinal outcomes research
VINTAGE MI
vascular interaction with age in myocardial infarction
VISION
vascular intervention study with ionizing radiation; sponsor: Guidant Corp. [Galileo™ intravascular radiotherapy system]
VISP
vitamin intervention for stroke prevention
VITATOPS
vitamins to prevent stroke
VIVA
VEGF (vascular endothelial growth factor) in ischemia for vascular angiogenesis
VMAC
vasodilation in the management of acute congestive heart failure;
WARCEF
warfarin-aspirin reduced cardiac ejection fraction
WARIS-II
warfarin-aspirin reinfarction study
WARSS
warfarin aspirin recurrent stroke study
WASID
warfarin-asprin symptomatic intracranial disease study
WATCH
warfarin & antiplatelet therapy in chronic CHF women atorvastatin trial on cholesterol
WAVE
women's angiographic vitamins and estrogen trial
WEARIT
wearable cardioverter-defibrillator investigational trial
WIHS
women's interagency HIV study
WINS
women’s intervention nutrition study
WISE
women's ischemia syndrome evaluation;
WIZARD
weekly intervention with Zithromax® against atherosclerosis and related disorders
Women's HOPE
Women's health, osteoporosis, progestin, and estrogen study
WRIST
Washington radiation for in-stent restenosis trial
XISHF
xamoterol in severe heart failure
X-TRACT
X-Sizer™ for treatment of thrombus and atherosclerosis in coronary interventions trial X-Sizer
ZEUS
Zomaril™ efficacy/utility and safety;
ZIPP
Zoladex® (goserelin acetate implant) in premenopausal patients
